eISSN: 1643-3750


A New Potential Predictor of Coronary Artery Disease: The Ratio of Mitral Peak Filling Velocity to Mitral Annular Velocity in Early Diastole

Li Ma, Yanhong Li, Zhisheng Wu, Yuming Mu

(Department of Echocardiography, First Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang, China (mainland))

Med Sci Monit 2017; 23:1180-1189

DOI: 10.12659/MSM.901704

Published: 2017-03-07

BACKGROUND: The aim of this study was to explore the value of the ratio of mitral peak filling velocity (E) to mitral annular velocity (e’) in early diastole as a predictor of coronary artery disease (CAD).
MATERIAL AND METHODS: The study population consisted of 83 consecutive patients (aged 38–77 years, 22 women and 61 men) who received coronary angiography. The E/e’ ratio was estimated by echocardiographic examination. Statistical significance was determined by receiver operating characteristic (ROC) curve and multiple logistic regression analyses.
RESULTS: ROC curve analysis showed that the optimal E/e’ ratio cut-off for predicting CAD was 8.153 with a specificity of 72.4% and sensitivity of 57.4%. The area under the ROC curve was 0.635 with a 95% confidence interval (CI) for normal distribution of 0.515–0.755 (p=0.043). Multivariate logistic regression analysis demonstrated that the E/e’ ratio was closely associated with CAD (odds ratio [OR], 1.350; 95% CI, 1.087–1.676, p=0.007).
CONCLUSIONS: The E/e’ ratio is a simple and practical predictor of CAD and may be an independent risk factor for CAD. Large-cohort and multi-center studies are required to confirm these observations.

Keywords: Atrial Function, Left, Coronary Disease, Heart Failure, Diastolic